منابع مشابه
Guiding Ligands to Nuclear Receptors
Retinoic acid-the active metabolite of vitamin A-influences biological processes by activating the retinoic acid receptor (RAR). In this issue, Schug et al. (2007) demonstrate that retinoic acid also activates the peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta). Remarkably, retinoic acid signaling through RAR or PPARbeta/delta-which depends on cytoplasmic retinoic acid tr...
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Nuclear receptors (NRs) are hormone-sensing transcription factors that translate dietary or endocrine signals into changes in gene expression. Therefore, the adoption of orphan NRs through the identification of their endogenous ligands is a key element for our understanding of their biology. In this minireview, we give an update on recent progress in regard to endogenous ligands for a cluster o...
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Nuclear hormone receptors comprise a large superfamily of ligand-modulated transcription factors that, in part, mediate response to steroids, retinoids and thyroid hormones and play key roles in development and body physiology (for review, see Beato et al. 1995; Kastner et al. 1995; Mangelsdorf and Evans 1995; Mangelsdorf et al. 1995; Enmark and Gustaffson 1996; Willy and Mangelsdorf 1998). Ten...
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Nuclear receptors are DNA-binding transcription factors, the transcriptional function of many of which depends on the binding of ligands, a feature that distinguishes nuclear receptors from other transcription factors. This review will summarize recent advances in our knowledge of the interaction between selected nuclear receptors and their cognate ligands.
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Classical signal transduction theory revolves around the premise that the role of membrane receptors is to transfer the signal represented by ligand binding from the external cell surface across the membrane to within the cell. Other components of the signaling cascade such as second-messenger molecules and kinases then convey the signal from the cytoplasm to the nucleus to effect changes in ge...
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ژورنال
عنوان ژورنال: Cell
سال: 2007
ISSN: 0092-8674
DOI: 10.1016/j.cell.2007.05.001